Bioequivalence analysis - two-period, two-treatment crossover trial

Input Values

Submit Data


Should data be log-transformed prior to analysis or not?
log-transform for analysis
Analysis on untransformed data
 
Data: Download example data
Note: When copying and pasting data from Excel, only the number of decimal places displayed in Excel will be copied. This may lead to small rounding errors if more decimal places are present in the original data.

Note: This page now accepts data where either a comma (,) or point (.) is used as the decimal separator.

Data Format

1. Select whether to log-transform the data or not

2. Enter data into a spreadsheet, copy it and paste it into the text box. The format requirements are:

Example data is provided in the spreadsheet downloadable from the link here. Use the CVM35 or Theophylline sheets for log-transformed data and Chow_71 for untransformed data.

  • at least five columns with label as listed below
    • id: a number or text label to identify each subject
    • treat: treatment identifier. (b>Note: Coding of treatment and reference groups should be such that the Reference group code precedes the treatment group code alphabetically or numerically. For example "R" for reference and "T" for treatment (or 1 and 2).
    • period: identifier for period (usually 1 or 2)
    • sequence: identifier for treatment sequence for each subject
    • value: the raw (untransformed) data value to be used in the analysis
  • include a header of column names
  • column order is unimportant
  • additional columns can be included and will be ignored

Outputs

Outputs are a table and plot of the following values:

  • analysis of variance table;
  • summary of period and sequence data;
  • summary table of mean differences;
  • bioequivalence comparisons; and
  • plot of IVP/RVP geometric means ratio.

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